I misunderstood. I thought you were asking about additional resistors for the 2-wire smoke.
All active (powered) but unused zones need a 3.3K ohm resistor to clear the trouble. Otherwise they will stay in trouble. If just using the CPU board you need 8 EOLR. If you reconnect the expansion zone modules you will need resistors for all those zones too.
All signal circuits need 10K ohm EOLR to clear the troubles on them.
I found a compatibility chart that the 6249B shows up on. It requires a 25 volt regulator module to work on the TFX loop in a 4100U/ES. The higher voltage on a 4002 zone probably would fry it.